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SARS-CoV-2 Spike Antibody
SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Antibody
產品編號: 3525
規  格:
單  價: 詢價
生 產 商: ProSci
到貨時間: 4-6weeks
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                                                             Figure 1 ELISA Test

 

BACKGROUND

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).


ALTERNATE NAMES
SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein.


CONJUGATE
Unconjugated


PURIFICATION
SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Antibody is affinity chromatography purified via peptide column.


HOST SPECIES
Rabbit


CLONALITY
Polyclonal


ISOTYPE
IgG


IMMUNOGEN
Anti-SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody (3525) was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike glycoprotein. The immunogen is located within the last 50 amino acids of SARS-CoV-2 (COVID-19, 2019- nCoV) Spike protein.


TESTED APPLICATIONS
ELISA


APPLICATIONS
SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody can be used for the detection of SARSCoV-2 (COVID-19, 2019-nCoV) Spike protein in ELISA. It will detect 4 ng of free peptide at 1 μg/mL.


BUFFER
SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Antibody is supplied in PBS containing 0.02% sodium azide.


STORAGE CONDITIONS
SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody can be stored at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.


SPECIES REACTIVITY
Virus

 

 

 

 

 

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